Comparative routes to 7-carboxymethyl-pterin: A useful medicinal chemistry building block

Abstract Pterins, such as folate and biopterin, their derivatives hold significant importance given biological relevance, well the numerous pterin-based inhibitors developed for targeting various targets. For this reason, pterins can be viewed a privileged scaffold , discovery of new pterin analogs gives rise to vast array potential drug candidates. 7-carboxymethyl-pterin (7-CMP) represents useful rapid generation structurally diverse amides has been key building block in medicinal chemistry. In an effort facilitate scaffold, we have explored multiple routes towards 7-CMP assess most efficient method generation. Methods were evaluated based on yield, regioselectivity, reaction time, hazardous conditions. This work aide synthesis